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To Werewolf or Not To Werewolf
Similar to Druid, one of the decisions you'll want to consider around getting your first combat skill to level 50 is if you are interested in all the benefits that come with being a Werewolf. Werewolves melee combat used to be exceptionally good and while it still is great, has been nerfed somewhat. The survivability and utility that comes from the life decision may also make leveling quicker and more enjoyable.
The main drawback is arguably much more hefty than the Druid decision at present, however. For three days each month, the full moon will be out and you will be forced to Wolf form. While this change may seem like a small tradeoff, three days is a very long time for some players who play on a daily basis anyway. This can hamstring any major projects, harvesting, or crafting you were planning on doing, especially if you needed to be in human form to do it.